Reaktion #475395

Reaktionsgleichung

{(2S)-1-[(Z)-1-butoxy-NNO-azoxy]pyrrolidin-2-yl}methanol

sodium periodate

→

title product

1-[(Z)-butoxy-NNO-azoxy]-L-proline

Lösungsmittel

CH3CN CCl4 H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe mixture was extracted with CH2Cl2 (3×50 mL)
2. 2
   Trocknendried over MgSO4
3. 3
   Einengenconcentrated

Vorschrift

To a solution of {(2S)-1-[(Z)-1-butoxy-NNO-azoxy]pyrrolidin-2-yl}methanol (360 mg, 1.66 mmol) and sodium periodate (1.06 g, 4.97 mmol) in 17.5 mL of CH3CN/CCl4/H2O (2:2:3) was added ruthenium(III) chloride hydrate (34 mg, 1.66 mmol). After stirring at rt over night, the mixture was extracted with CH2Cl2 (3×50 mL), dried over MgSO4 and concentrated to give the title product, which was used directly.

Quelle