Reaktion #475368

Reaktionsgleichung

1,3-dibromobenzene

5H-pyrido[4,3-b]indole

potassium carbonate

dimethyl sulfoxide

→

5-(3-bromophenyl)-5H-pyrido[4,3-b]indole

Ausbeute 62.0%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturby heating
2. 2
   TemperaturAfter cooling to room temperature
3. 3
   Sonstigethe insoluble materials were removed by filtration
4. 4
   Einengenthe filtrate was concentrated under reduced pressure
5. 5
   Sonstigeto obtain a crude product
6. 6
   SonstigeThe crude product was purified by column chromatography (carrier: silica gel, eluent: hexane/chloroform)

Vorschrift

Another reaction vessel was charged with 17.2 ml of 1,3-dibromobenzene, 6.0 g of 5H-pyrido[4,3-b]indole, 1.1 g of copper powder, 9.9 g of potassium carbonate, and 0.6 ml of dimethyl sulfoxide, followed by heating and stirring at 180° C. for 4 hours. After cooling to room temperature, 50 ml of chloroform was added thereto, the insoluble materials were removed by filtration and the filtrate was concentrated under reduced pressure to obtain a crude product. The crude product was purified by column chromatography (carrier: silica gel, eluent: hexane/chloroform) to obtain 7.1 g (yield 62%) of 5-(3-bromophenyl)-5H-pyrido[4,3-b]indole as a white powder.

Quelle