Reaktion #4744

Reaktionsgleichung

ammonia

3-hydroxybenzaldehyde

3-methylpiperidine

formic acid

→

3-[(3-Methylpiperidin-1-yl)methyl]phenol

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwith cooling
2. 2
   TemperaturWhen the reaction mixture has cooled to room temperature
3. 3
   Filtrationthe precipitated solid is filtered off
4. 4
   Sonstigerecrystallised from ethanol

Vorschrift

24.4 g (0.2 mol) of 3-hydroxybenzaldehyde are mixed with 40 ml (about 0.4 mol) of 3-methylpiperidine and 20 ml (about 0.52 mol) of 100% formic acid with cooling and then stirred for 2 hours at 120° C. When the reaction mixture has cooled to room temperature, it is poured into water and rendered alkaline with ammonia, and the precipitated solid is filtered off and recrystallised from ethanol.

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