Reaktion #474332

ord-f9b0a74a3ea64028bf8a62544dbb65c1

Reaktionsgleichung

CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
NaBH(OAc)3
CCCc1cc(CCC=O)n(-c2ccccc2)n1
3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propanal
Clc1ccc(N2CCNCC2)cc1Cl
1-(3,4-dichlorophenyl)piperazine
CCN(C(C)C)C(C)C
DIPEA
→
CCCc1cc(CCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)n(-c2ccccc2)n1
1-(3,4-dichlorophenyl)-4-(3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propyl)piperazine

Edukte

CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
NaBH(OAc)3
CCCc1cc(CCC=O)n(-c2ccccc2)n1
3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propanal
Clc1ccc(N2CCNCC2)cc1Cl
1-(3,4-dichlorophenyl)piperazine
CCN(C(C)C)C(C)C
DIPEA

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstige192 mg (94%) of target compound was obtained

Vorschrift

192 mg (94%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propanal (100 mg, 0.413 mmol), 1-(3,4-dichlorophenyl)piperazine (95 mg, 0.413 mmol), DIPEA (0.110 mL, 0.620 mmol) and NaBH(OAc)3 (263 mg, 1.239 mmol).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08372844B2uspto-grants-2013_02