Reaktion #474182

ord-edcc087a8e2a4133bbd23c1a4077b362

Reaktionsgleichung

CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
NaBH(OAc)3
O=CCCc1cc(-c2ccccc2)n(-c2ccccc2)n1
3-(1,5-diphenyl-1H-pyrazol-3-yl)propanal
c1ccc(N2CCNCC2)cc1
1-phenylpiperazine
CCN(C(C)C)C(C)C
DIPEA
→
c1ccc(-c2cc(CCCN3CCN(c4ccccc4)CC3)nn2-c2ccccc2)cc1
1-phenyl-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine

Edukte

CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
NaBH(OAc)3
O=CCCc1cc(-c2ccccc2)n(-c2ccccc2)n1
3-(1,5-diphenyl-1H-pyrazol-3-yl)propanal
c1ccc(N2CCNCC2)cc1
1-phenylpiperazine
CCN(C(C)C)C(C)C
DIPEA

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstige100 mg (94%) of target compound was obtained

Vorschrift

100 mg (94%) of target compound was obtained by using a method same as in Example 1 by using 3-(1,5-diphenyl-1H-pyrazol-3-yl)propanal (76 mg, 0.275 mmol), 1-phenylpiperazine (0.038 mL, 0.250 mmol), DIPEA (44 mL, 0.250 mmol) and NaBH(OAc)3 (185 mg, 0.875 mmol).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08372844B2uspto-grants-2013_02