Reaktion #473882

ord-f29953d08c4b4f45a8e7512ec32bc4a4

Reaktionsgleichung

3-[3-(2-ethoxycarbonyl-ethyl)-ureido]-benzoic acid

$Cl.Nc1nc(N)c(C(=O)/N=C2\NCC3(CCNCC3)N2)nc1Cl$

3,5-diamino-6-chloro-pyrazine-2-carboxylic acid [1,3,8-triaza-spiro[4.5]dec-(2E)-ylidene]-amide hydrochloride

→

$CCOC(=O)CCNC(=O)Nc1cccc(C(=O)N2CCC3(CC2)CN/C(=N\C(=O)c2nc(Cl)c(N)nc2N)N3)c1$

title compound

$CCOC(=O)CCNC(=O)Nc1cccc(C(=O)N2CCC3(CC2)CN/C(=N\C(=O)c2nc(Cl)c(N)nc2N)N3)c1$

3-[3-(3-{2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8-triaza-spiro[4.5]decane-8-carbonyl}-phenyl)-ureido]-propionic acid ethyl ester

Edukte

3-[3-(2-ethoxycarbonyl-ethyl)-ureido]-benzoic acid

$Cl.Nc1nc(N)c(C(=O)/N=C2\NCC3(CCNCC3)N2)nc1Cl$

3,5-diamino-6-chloro-pyrazine-2-carboxylic acid [1,3,8-triaza-spiro[4.5]dec-(2E)-ylidene]-amide hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen

See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from 3-[3-(2-ethoxycarbonyl-ethyl)-ureido]-benzoic acid (Int. F) and 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid [1,3,8-triaza-spiro[4.5]dec-(2E)-ylidene]-amide hydrochloride using an analogous method to Example 1; LC-MS Rt 0.81 mins; 587.4 and 589.3 [M+H]+, Method 2minLC_v003.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08372845B2uspto-grants-2013_02