Reaktion #473874

ord-df89a7930aea4a56b459e5ffae1a35f8

Reaktionsgleichung

CC(C)(C)OC(=O)CCNS(=O)(=O)c1cccc(C(=O)O)c1

3-(2-tert-butoxycarbonyl-ethylsulfamoyl)-benzoic acid

$Cl.Nc1nc(N)c(C(=O)/N=C2\NCC3(CCNCC3)N2)nc1Cl$

3,5-diamino-6-chloro-pyrazine-2-carboxylic acid [1,3,8-triaza-spiro[4.5]dec-(2E)-ylidene]-amide hydrochloride

→

$CC(C)(C)OC(=O)CCNS(=O)(=O)c1cccc(C(=O)N2CCC3(CC2)CN/C(=N\C(=O)c2nc(Cl)c(N)nc2N)N3)c1$

title compound

$CC(C)(C)OC(=O)CCNS(=O)(=O)c1cccc(C(=O)N2CCC3(CC2)CN/C(=N\C(=O)c2nc(Cl)c(N)nc2N)N3)c1$

3-(3-{2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8-triaza-spiro[4.5]decane-8-carbonyl}-benzenesulfonylamino)-propionic acid tert-butyl ester

Edukte

3-(2-tert-butoxycarbonyl-ethylsulfamoyl)-benzoic acid

$Cl.Nc1nc(N)c(C(=O)/N=C2\NCC3(CCNCC3)N2)nc1Cl$

3,5-diamino-6-chloro-pyrazine-2-carboxylic acid [1,3,8-triaza-spiro[4.5]dec-(2E)-ylidene]-amide hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen

See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from 3-(2-tert-butoxycarbonyl-ethylsulfamoyl)-benzoic acid (Int. AD) and 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid [1,3,8-triaza-spiro[4.5]dec-(2E)-ylidene]-amide hydrochloride in an analogous method to Example 1; LC-MS Rt 0.93 mins; 636.3 [M+H]+, Method 2minLC_v003.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08372845B2uspto-grants-2013_02