Reaktion #473852

Reaktionsgleichung

(4-(imidazol-1-yl)-phenyl]-3-benzyloxy-6-amino-4H-1-benzopyran-4-one

acetonitrile

→

titled compound

Ausbeute 73.0%

(4-(imidazol-1-yl)-phenyl]-3-benzyloxy-6-[(1-iminoethyl)amino]-4H-1-benzopyran-4-one

Ausbeute 73.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeHCl was bubbled into the solution upon saturation
2. 2
   workup.ADDITIONwas added
3. 3
   Sonstigethe acetonitrile removed under vacuum
4. 4
   Filtrationthe precipitate was filtered off
5. 5
   Sonstigedried

Vorschrift

2-[(4-(imidazol-1-yl)-phenyl]-3-benzyloxy-6-amino-4H-1-benzopyran-4-one (3 g; 6.22 mmol) was suspended in acetonitrile (50 mL) and cooled at 0° C. HCl was bubbled into the solution upon saturation. The reaction was then stirred for 4 hours at r.t., upon completion, H2O (20 mL) was added and the acetonitrile removed under vacuum. The solution was then brought to pH=9 with NaOH 2N, the precipitate was filtered off and dried to give the titled compound as a bright yellow solid. Yield: 73%. TLC: (9/1 Chloroform/Methanol) Rf: 0.6.

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