Reaktion #473693

Reaktionsgleichung

5-hydroxy-2-adamantanone

dimethylaminopyridine

acetic anhydride

→

title compound

Acetic acid 2-oxo-adamantan-5-yl ester

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed under reduced pressure
2. 2
   Sonstigethe residue was partitioned between water and ethyl acetate
3. 3
   ExtraktionThe aqueous layer was extracted twice with ethyl acetate
4. 4
   WaschenCombined organic extracts were washed with water
5. 5
   Trocknendried (MgSO4)
6. 6
   Filtrationfiltered
7. 7
   EinengenThe filtrate was concentrated under reduced pressure

Vorschrift

A solution of 5-hydroxy-2-adamantanone (2.6 g, 15.66 mmoles) in dichloromethane (DCM) (50 mL) was treated with dimethylaminopyridine (DMAP) (2.1 g, 17 mmoles) and acetic anhydride (2.3 mL, 23 mmoles) and stirred overnight at 50° C. The solvent was removed under reduced pressure and the residue was partitioned between water and ethyl acetate. The aqueous layer was extracted twice with ethyl acetate. Combined organic extracts were washed with water, dried (MgSO4) and filtered. The filtrate was concentrated under reduced pressure to provide the title compound as an off-white solid.

Quelle