Reaktion #473468

ord-ee4443b81b9e40939e36ef6f4b97b388

Reaktionsgleichung

7-chloro-4-methoxy-2-phenylquinazoline

Cc1nc(-c2ccccc2)nc2cc(B3OC(C)(C)C(C)(C)O3)ccc12

4-methyl-2-phenyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline

→

COc1nc(-c2ccccc2)nc2cc(B3OC(C)(C)C(C)(C)O3)ccc12

4-Methoxy-2-phenyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline

Edukte

—

( 100 )

7-chloro-4-methoxy-2-phenylquinazoline

4-methyl-2-phenyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline

—

( 20 )

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen

See reaction.notes.procedure_details.

Aufarbeitung

1
SonstigeHPLC: tR=3.19 min (OpenLynx, polar—5 min)

Vorschrift

Synthesized from of 7-chloro-4-methoxy-2-phenylquinazoline (189 mg, 0.7 mmol) as 4-methyl-2-phenyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline; off-white solid. MS (ES+): m/z 347.2 (20) MS (ES+): m/z 281.2 (100) [MH+-82]; HPLC: tR=3.19 min (OpenLynx, polar—5 min).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08367826B2uspto-grants-2013_02