Reaktion #47331

Reaktionsgleichung

3-chloro-2-fluoro-phenol

ethyl-2-butynoate

1,8-diazabicyclo[5.4.0]undec-7-ene

→

3-(3-chloro-2-fluoro-phenoxy)-but-2-enoic acid ethyl ester

Ausbeute 61.0%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAt this time, the reaction was cooled to 25° C.
2. 2
   EinengenAt this time, the reaction was concentrated in vacuo
3. 3
   workup.DISSOLUTIONThe residue was dissolved in dichloromethane (100 mL)
4. 4
   Waschenwas washed with a 2N aqueous hydrochloric acid solution (1×100 mL)
5. 5
   TrocknenThe organics were then dried over magnesium sulfate
6. 6
   Filtrationfiltered
7. 7
   Waschenrinsed with dichloromethane
8. 8
   Einengenconcentrated in vacuo
9. 9
   SonstigePurification by Analogix flash chromatography (40 g, 1-10% ethyl acetate/hexanes)

Vorschrift

A mixture of 3-chloro-2-fluoro-phenol (1.31 g, 8.93 mmol) and ethyl-2-butynoate (2.0 g, 17.83 mmol) in tetrahydrofuran (14 mL) was treated with 1,8-diazabicyclo[5.4.0]undec-7-ene (1.4 mL, 9.37 mmol). The reaction was then heated at 130° C. for 2 h. At this time, the reaction was cooled to 25° C. and was stirred at 25° C. overnight. At this time, the reaction was concentrated in vacuo. The residue was dissolved in dichloromethane (100 mL) and was washed with a 2N aqueous hydrochloric acid solution (1×100 mL), a 1N aqueous sodium hydroxide solution (1×100 mL) and a saturated aqueous sodium chloride solution (1×100 mL). The organics were then dried over magnesium sulfate, filtered, rinsed with dichloromethane, and concentrated in vacuo. Purification by Analogix flash chromatography (40 g, 1-10% ethyl acetate/hexanes) afforded 3-(3-chloro-2-fluoro-phenoxy)-but-2-enoic acid ethyl ester (1.41 g, 61%) as a white solid: HR-ES-MS m/z calculated for C12H12O3FCl [M+H]+ 259.0532, observed 259.0531; 1H NMR (400 MHz, DMSO-d6) δ ppm 1.14 (t, J=7.1 Hz, 3H), 2.45 (s, 3H), 4.03 (q, J=7.1 Hz, 2H), 4.76 (s, 1H), 7.27-7.39 (m, 2H), 7.50-7.61 (m, 1H).

Quelle