Reaktion #472775

Reaktionsgleichung

2-chloro-5-fluoropyridin-3-amine

pyridine

water

ethyl acetate

→

N-(2-chloro-5-fluoropyridin-3-yl)-2-methylacrylamide

Lösungsmittel

2-methylacryloyl chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder cooling with ice
2. 2
   Sonstigethe organic layer was separated
3. 3
   Extraktionthe aqueous layer was extracted with ethyl acetate
4. 4
   Waschenthe resultant solution was washed sequentially with water
5. 5
   Trocknena saturated aqueous sodium chloride solution, and dried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
7. 7
   SonstigeThe resultant residue was purified by flash silica gel column chromatography
8. 8
   Waschenelution with hexane

Vorschrift

To a solution of 1.2 g of 2-chloro-5-fluoropyridin-3-amine in 5 mL of pyridine, 0.86 mL of 2-methylacryloyl chloride was added under cooling with ice, and the mixture was stirred at room temperature for 30 minutes. To the reaction mixture, water and ethyl acetate were added, the organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layer and the extract were combined, the resultant solution was washed sequentially with water and a saturated aqueous sodium chloride solution, and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The resultant residue was purified by flash silica gel column chromatography using gradient elution with hexane:ethyl acetate=100:0 to 50:50 to obtain 1.1 g of N-(2-chloro-5-fluoropyridin-3-yl)-2-methylacrylamide as a colorless oily substance.

Quelle