Reaktion #47255

Reaktionsgleichung

(R)-3-(3-nitro-pyrazol-1-yl)-propane-1,2-diol

hydrogen

→

(R)-3-(3-amino-pyrazol-1-yl)-propane-1,2-diol

Ausbeute 98.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction was then filtered through a pad of celite
2. 2
   Waschenwashed with ethanol
3. 3
   Einengenconcentrated in vacuo

Vorschrift

In a Parr shaker bottle was placed (R)-3-(3-nitro-pyrazol-1-yl)-propane-1,2-diol (3.17 g, 16.95 mmol), 10% palladium on activated carbon (200 mg) and ethanol (30 mL). The bottle was then placed on the Parr shaker at 50 psi of hydrogen pressure for 5 h. The reaction was then filtered through a pad of celite and washed with ethanol and concentrated in vacuo to afford (R)-3-(3-amino-pyrazol-1-yl)-propane-1,2-diol (2.60 g, 98%) as a yellow oil: LR-ES-MS m/z calculated for C6H11N3O2 [M]+ 157, observed [M+H]+ 158.

Quelle