Reaktion #472297

Reaktionsgleichung

4-benzyloxy-3-trifluoromethylbenzoic acid

toluene

thionyl chloride

→

4-benzyloxy-3-trifluoromethylbenzoyl chloride

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
2. 2
   Sonstigeazeotroped with toluene
3. 3
   Sonstigethe obtained product was used for the synthesis of (h)

Vorschrift

To 4-benzyloxy-3-trifluoromethylbenzoic acid (444 mg), toluene (5 mL), N,N-dimethylformamide (2 droplets) and thionyl chloride (0.16 mL) were added, and then the mixture was stirred at 60° C. for 20 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene, and the obtained product was used for the synthesis of (h).

Quelle