Reaktion #472289

Reaktionsgleichung

4-benzyloxy-3-methoxy-5-trifluoromethylbenzoic acid

toluene

thionyl chloride

→

title compound

4-benzyloxy-3-methoxy-5-trifluoromethylbenzoyl chloride

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
2. 2
   Sonstigeazeotroped with toluene

Vorschrift

To 4-benzyloxy-3-methoxy-5-trifluoromethylbenzoic acid (601 mg), toluene (6 mL), N,N-dimethylformamide (1 droplet) and thionyl chloride (0.16 mL) were added, and then the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene to obtain the title compound (657 mg) as a yellow oily substance.

Quelle