Reaktion #472261

Reaktionsgleichung

3-chloro-4-methoxy-5-trifluoromethylbenzoic acid

toluene

thionyl chloride

→

3-chloro-4-methoxy-5-trifluoromethylbenzoyl chloride

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
2. 2
   Sonstigethe obtained residue was azeotroped with toluene
3. 3
   Sonstigeused for the synthesis of (e)

Vorschrift

To 3-chloro-4-methoxy-5-trifluoromethylbenzoic acid (300 mg), toluene (3 mL), N,N-dimethylformamide (1 droplet) and thionyl chloride (0.13 mL) were added, and the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and the obtained residue was azeotroped with toluene and used for the synthesis of (e).

Quelle