Reaktion #472142

ord-5e610819da794f64b32c31a975001c06

Reaktionsgleichung

CON(C)C(=O)C(NC(=O)OC(C)(C)C)c1ccc(C)c(Cl)c1
rac-[(3-chloro-4-methyl-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester
CON(C)C(=O)C(NC(=O)OC(C)(C)C)c1ccc(C)c(Cl)c1
Intermediate 4
CON(C)C(=O)C(NC(=O)OC(C)(C)C)c1ccc(C)c(Cl)c1
rac-[(3-chloro-4-methyl-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester
Ic1ccc(I)cc1
1,4-di-iodobenzene
Cc1ccc(C(NC(=O)OC(C)(C)C)C(=O)c2ccc(I)cc2)cc1Cl
title compound
Cc1ccc(C(NC(=O)OC(C)(C)C)C(=O)c2ccc(I)cc2)cc1Cl
rac-[1-(3-Chloro-4-methyl-phenyl)-2-(4-iodo-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from rac-[(3-chloro-4-methyl-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 4) and 1,4-di-iodobenzene in analogy to Example 1a): MS (ISN): 484.2 (M−H)−.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08367838B2uspto-grants-2013_02