Reaktion #472139

ord-0aafa4a8d01e4a4ca10a7cabff38be61

Reaktionsgleichung

CON(C)C(=O)C(NC(=O)OC(C)(C)C)c1ccc(C(F)(F)F)cc1
rac-[(methoxy-methyl-carbamoyl)-(4-trifluoromethyl-phenyl)-methyl]-carbamic acid tert-butyl ester
CON(C)C(=O)C(NC(=O)OC(C)(C)C)c1ccc(C(F)(F)F)cc1
Intermediate 10
CON(C)C(=O)C(NC(=O)OC(C)(C)C)c1ccc(C(F)(F)F)cc1
rac-[(methoxy-methyl-carbamoyl)-(4-trifluoromethyl-phenyl)-methyl]-carbamic acid tert-butyl ester
Ic1ccc(I)cc1
1,4-di-iodobenzene
→
CC(C)(C)OC(=O)NC(C(=O)c1ccc(I)cc1)c1ccc(C(F)(F)F)cc1
title compound
CC(C)(C)OC(=O)NC(C(=O)c1ccc(I)cc1)c1ccc(C(F)(F)F)cc1
rac-[2-(4-Iodo-phenyl)-2-oxo-1-(4-trifluoromethyl-phenyl)-ethyl]-carbamic acid tert-butyl ester

Edukte

CON(C)C(=O)C(NC(=O)OC(C)(C)C)c1ccc(C(F)(F)F)cc1
rac-[(methoxy-methyl-carbamoyl)-(4-trifluoromethyl-phenyl)-methyl]-carbamic acid tert-butyl ester
CON(C)C(=O)C(NC(=O)OC(C)(C)C)c1ccc(C(F)(F)F)cc1
Intermediate 10
CON(C)C(=O)C(NC(=O)OC(C)(C)C)c1ccc(C(F)(F)F)cc1
rac-[(methoxy-methyl-carbamoyl)-(4-trifluoromethyl-phenyl)-methyl]-carbamic acid tert-butyl ester
Ic1ccc(I)cc1
1,4-di-iodobenzene

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from rac-[(methoxy-methyl-carbamoyl)-(4-trifluoromethyl-phenyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 10) and 1,4-di-iodobenzene in analogy to Example 1a): MS (ISN): 504.0 (M−H)−.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08367838B2uspto-grants-2013_02