Reaktion #471980

Reaktionsgleichung

methyl 5-methoxy-4-(3-chloropropoxy)-2-nitrobenzoate

hydrogen

→

methyl 5-methoxy-4-(3-chloropropoxy)anthranilate

Ausbeute 95.2%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn a 50 mL volume glass flask equipped with a stirrer
2. 2
   workup.ADDITIONwas introduced to the mixture under atmospheric pressure at a rate of 50 mL/min
3. 3
   Filtrationthe reaction mixture was filtered

Vorschrift

In a 50 mL volume glass flask equipped with a stirrer, a thermometer, a reflux condenser and a gas inlet were placed 1.01 g (3.29 mmol) of methyl 5-methoxy-4-(3-chloropropoxy)-2-nitrobenzoate (purity: 99%) obtained in Reference Example III-4, 0.46 g of 10 wt. % palladium/carbon and 16 mL of methanol. The resulting mixture was heated to 30° C. for 2 hours, while hydrogen was introduced to the mixture under atmospheric pressure at a rate of 50 mL/min. After the reaction was complete, the reaction mixture was filtered. The filtrate was analyzed by high performance liquid chromatography (absolute quantitative analysis). There was produced 0.85 g (reaction yield: 95.2%) of methyl 5-methoxy-4-(3-chloropropoxy)anthranilate.

Quelle