Reaktion #471979

Reaktionsgleichung

methyl 5-methoxy-4-(3-chloropropoxy)-2-nitrobenzoate

→

methyl 5-methoxy-4-(3-chloropropoxy)-anthranilate

Ausbeute 85.5%

Lösungsmittel

formic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn a 50 mL volume glass flask equipped with a stirrer
2. 2
   Filtrationthe reaction mixture was filtered

Vorschrift

In a 50 mL volume glass flask equipped with a stirrer, a thermometer and a reflux condenser were placed 1.01 g (3.29 mmol) of methyl 5-methoxy-4-(3-chloropropoxy)-2-nitrobenzoate (purity: 99%) obtained in Reference Example III-4, 1.0 g of a developed Raney nickel, and 10 mL of formic acid. The reaction was carried out at 70° C. for 8 hours. After the reaction was complete, the reaction mixture was filtered. The filtrate was analyzed by high performance liquid chromatography (absolute quantitative analysis). There was produced 0.77 g (reaction yield: 85.0%) of methyl 5-methoxy-4-(3-chloropropoxy)-anthranilate.

Quelle