Reaktion #471977

Reaktionsgleichung

hydrogen

methyl 5-methoxy-4-(3-chloropropoxy)-2-nitrobenzoate

→

methyl 5-methoxy-4-(3-chloropropoxy)anthranilate

Ausbeute 98.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn a 50 mL volume glass flask equipped with a stirrer
2. 2
   Filtrationthe reaction mixture was filtered

Vorschrift

In a 50 mL volume glass flask equipped with a stirrer, a thermometer, a reflux condenser and a balloon containing hydrogen gas were placed 1.01 g (3.29 mmol) of methyl 5-methoxy-4-(3-chloropropoxy)-2-nitrobenzoate (purity: 99%) obtained in Reference Example III-4, 0.2 g of 3 wt. % platinum sulfide/carbon (containing 65.7% water), and 40 mL of methanol. The reaction was carried out at 40° C. for 8 hours. After the reaction was complete, the reaction mixture was filtered. The filtrate was analyzed by high performance liquid chromatography (absolute quantitative analysis). There was produced 0.88 g (reaction yield: 98.0%) of methyl 5-methoxy-4-(3-chloropropoxy)anthranilate.

Quelle