Reaktion #471976

Reaktionsgleichung

methyl 5-methoxy-4-(3-chloropropoxy)-2-nitrobenzoate

hydrogen

hydrogen

→

methyl 5-methoxy-4-(3-chloropropoxy)anthranilate

Ausbeute 95.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIn a 50 mL volume pressure-resistant vessel were placed
2. 2
   Sonstigethe vessel was closed
3. 3
   Filtrationthe reaction mixture was filtered

Vorschrift

In a 50 mL volume pressure-resistant vessel were placed 2.02 g (6.58 mmol) of methyl 5-methoxy-4-(3-chloropropoxy)-2-nitrobenzoate (purity: 99%) obtained in Reference Example III-4, 2.0 g of a developed Raney nickel, and 40 mL of methanol. The atmosphere in the vessel was replaced with hydrogen, and the vessel was closed. The reaction was carried out at 90-100° C. for 24 hours at a hydrogen pressure of 0.9 MPa (gauge pressure). After the reaction was complete, the reaction mixture was filtered. The filtrate was analyzed by high performance liquid chromatography (absolute quantitative analysis). There was produced 1.71 g (reaction yield: 95.0%) of methyl 5-methoxy-4-(3-chloropropoxy)anthranilate.

Quelle