Reaktion #471930

Reaktionsgleichung

ammonium chloride

methyl 4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoate

→

methyl 2-amino-4-(3-chloropropoxy)-5-methoxybenzoate

Ausbeute 90.0%

Lösungsmittel

methanol

water

Reaktionsbedingungen

Vorschrift

JP-A-2001-519788 describes a process for preparing a 5-alkoxy-4-halogenoalkoxyanthranilic acid compound from a 5-alkoxy-4-halogenoalkoxy-2-nitrobenzoic acid compound. For example, methyl 4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoate is reacted with a very excessive amount of iron and ammonium chloride in a mixture of water and methanol, to give methyl 2-amino-4-(3-chloropropoxy)-5-methoxybenzoate (i.e., ethyl 4-(3-chloropropoxy)-5-methoxyanthranilate) in 90% yield.

Quelle