Reaktion #471568

Reaktionsgleichung

5-(3-Amino-2-methoxy-5-methyl-phenyl)-furan-2-carboxylic acid

5-(3-amino-2-methoxy-5-methyl-phenyl)-furan-2-carboxylic acid

boron tribromide

→

5-(3-amino-2-hydroxy-5-methyl-phenyl)-furan-2-carboxylic acid hydrobromide

Ausbeute 54.7%

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture was reacted at room temperature for 2 hours
2. 2
   EinengenThe mixture was concentrated under reduced pressure
3. 3
   WaschenThe resulting residue was washed with ethyl acetate (50 mL×3)
4. 4
   Sonstigedried

Vorschrift

5-(3-Amino-2-methoxy-5-methyl-phenyl)-furan-2-carboxylic acid 46b (248 mg, 1 mmol) was dissolved in 20 mL of dichloromethane followed by dropwise addition of a solution of boron tribromide in dichloromethane (3 mL, 1 mmol/L). The reaction mixture was reacted at room temperature for 2 hours. The reaction was monitored by TLC until the disappearance of the starting materials. The mixture was concentrated under reduced pressure. The resulting residue was washed with ethyl acetate (50 mL×3) and dried to obtain the title compound 5-(3-amino-2-hydroxy-5-methyl-phenyl)-furan-2-carboxylic acid hydrobromide 46c (172 mg, yield 54.7%) as a white solid.

Quelle