Reaktion #4712

Reaktionsgleichung

methylisothiocyanate

N-[3-[3-(1-piperidinylmethyl) phenoxy]propyl]-hydrazine carboxamide

→

2-(Methylaminothioxomethyl)-N-[3-[3-(1-piperidinylmethyl)phenoxy]-propyl]-hydrazine carboxamide

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe precipitate obtained
2. 2
   Filtrationis filtered off
3. 3
   Sonstigerecrystallised from ethanol

Vorschrift

0.5 g (6.6 mmol) of methylisothiocyanate are added to 1.0 g (3.3 mmol) of N-[3-[3-(1-piperidinylmethyl) phenoxy]propyl]-hydrazine carboxamide in 20 ml of THF and the mixture is stirred at room temperature for 12 hours. The precipitate obtained is filtered off and recrystallised from ethanol. The analytical values are summarized in Table I.

Quelle