Reaktion #47101

Reaktionsgleichung

dicyclopropylmethan-1-ol

ethyl diazoacetate

→

product 448

Ausbeute 52.1%

(Dicyclopropylmethoxy)acetic acid ethyl ester

Ausbeute 52.1%

Lösungsmittel

heptane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered
2. 2
   SonstigeThe filtrate is evaporated
3. 3
   workup.DISTILLATIONdistilled at 170° C.

Vorschrift

To a solution of dicyclopropylmethan-1-ol (1.5 mL, 12.7 mmol) in dichloromethane (20 mL) is added rhodium (II) acetate dimer (10 mg) followed by ethyl diazoacetate (1.26 mL, 12.0 mmol). The reaction mixture is stirred at rt for 48 h. The reaction mixture is diluted with heptane, and filtered. The filtrate is evaporated, and the residue is vacuum distilled at 170° C. to give 1.24 g of the product 448.

Quelle