Reaktion #47085

Reaktionsgleichung

Et2O

thiophenol

potassium carbonate

ethyl bromoacetate

→

product 400

Ausbeute 89.8%

(Phenylthio)acetic acid ethyl ester

Ausbeute 89.8%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenthe mixture is washed with water, brine
2. 2
   Trocknendried (MgSO4)
3. 3
   Filtrationfiltered
4. 4
   SonstigeThe filtrate is evaporated
5. 5
   workup.DISTILLATIONdistilled (130-140° C.)

Vorschrift

To a solution of thiophenol (1 mL, 9.7 mmol) in DMF (20 mL) is added potassium carbonate (1.51 g, 10.9 mmol) and ethyl bromoacetate (1.17 mL, 10.6 mmol), and the mixture is stirred at RT for 25 min. Et2O is added, and the mixture is washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue is vacuum distilled (130-140° C.) to give 1.71 g of the product 400. 1H NMR (CDCl3) δ 7.41 (d, 2H), 7.33-7.2 (m, 4H), 4.16 (q, 2H), 3.63 (s, 2H), 1.22 (t, 3H); MS: m/z 196 (M++1).

Quelle