Reaktion #470812

Reaktionsgleichung

diisopropyl azodicarboxylate

6-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2H-pyridazin-3-one

3-aminobenzyl alcohol

triphenylphosphine

→

2-(3-Aminobenzyl)-6-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2H-pyridazin-3-one

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe reaction mixture is stirred at room temperature for 3 hours
2. 2
   Sonstigesubsequently evaporated
3. 3
   workup.STIRRINGthe mixture is stirred for 15 minutes
4. 4
   FiltrationThe residue is filtered off with suction
5. 5
   Waschenwashed well with 2-propanol
6. 6
   SonstigeThe residue is dried in vacuo

Vorschrift

2.5 g (10 mmol) of 6-[4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-2H-pyridazin-3-one, 1.85 g (15 mmol) of 3-aminobenzyl alcohol and 3.9 g (15 mmol) of triphenylphosphine are suspended in 60 ml of THF under a nitrogen atmosphere, and the mixture is stirred at room temperature for 10 min. 2.9 g (15 mmol) of diisopropyl azodicarboxylate is then added dropwise over the course of 15 min. The reaction mixture is stirred at room temperature for 3 hours and subsequently evaporated. The residue is taken up in about 70 ml of 2-propanol, and the mixture is stirred for 15 minutes. The residue is filtered off with suction, washed well with 2-propanol, then with MTBE. The residue is dried in vacuo.

Quelle