Reaktion #47077

Reaktionsgleichung

chloroacetonitrile

2-fluorophenol

potassium carbonate

→

product 384

Ausbeute 97.4%

(2-Fluorophenoxy)acetonitrile

Ausbeute 97.4%

Lösungsmittel

EtOAc

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is cooled to RT
2. 2
   Waschenwashed with water, brine
3. 3
   Trocknendried (MgSO4)
4. 4
   Filtrationfiltered
5. 5
   SonstigeThe filtrate is evaporated
6. 6
   Sonstigethe residue purified by chromatography on silica gel
7. 7
   Waschenelution with dichloromethane

Vorschrift

To a solution of 2-fluorophenol (560 mg, 5.0 mmol) in DMF (10 mL) is added potassium carbonate (828 mg, 6.0 mmol) followed by chloroacetonitrile (0.315 mL, 50.0 mmol). The reaction mixture is stirred and heated at 50° C. for 14 h. The reaction mixture is cooled to RT, diluted with EtOAc, and washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue purified by chromatography on silica gel; elution with dichloromethane gives 736 mg of the product 384.

Quelle