Reaktion #470735

Reaktionsgleichung

3-chloro-4,6-diphenylpyridazine

1-(2-pyrimidyl)piperazine

→

4,6-diphenyl-3-(4-pyrimidin-2-ylpiperazin-1-yl)pyridazine

Ausbeute 81.1%

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   SonstigeThe solvent was removed by evaporation in vacuo
3. 3
   workup.ADDITIONthe residue was treated with water
4. 4
   Sonstigeto give a suspension
5. 5
   FiltrationThe solid was then filtered off
6. 6
   Waschenwashed with water
7. 7
   Sonstigedried
8. 8
   Filtrationover filter funnel in vacuo
9. 9
   Sonstigeto give light pink solid

Vorschrift

A mixture of 3-chloro-4,6-diphenylpyridazine (267 mg, 11.0 mmol), 1-(2-pyrimidyl)piperazine (656 mg, 4.0 mmol) in 3 ml of 1-BuOH was heated with stirring at 130 C for 3 days. The solvent was removed by evaporation in vacuo, the residue was treated with water to give a suspension. The solid was then filtered off, washed with water, dried over filter funnel in vacuo to give light pink solid. (320 mg, 0.81 mmol, yield 81.1%). ESI-MS: m/z 395.5 (M+H+). HRMS calcd 395.1979. found 395.1973. 1H NMR (CDCl3): d 8.329 (d, J=5.0, 2H), 8.101 (d, J=7.5, 2H), 7.734 (d, J=7.5, 2H), 7.655 (s, 1H), 7.509 (m, 6H), 6.530 (t, J=4.5, 1H), 3.836 (t, J=4.5, J=5.0, 4H), 3.394 (t, J=5.0, J=4.5, 4H).

Quelle