Reaktion #470730

Reaktionsgleichung

3-chloro-6-phenyl-4-(pyridin-4-yl)pyridazine

2-Morpholin-4-yl-ethylamine

3-(4-methylpiperazin-1-yl)-N-(2-morpholinoethyl)-6-phenyl-4-(pyridin-4-yl)pyridazin-3-amine

→

N-(2-morpholinoethyl)-6-phenyl-4-(pyridin-4-yl)pyridazin-3-amine

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   SonstigeThe solvent was removed by evaporation in vacuo
3. 3
   workup.ADDITIONthe residue was treated with water
4. 4
   Sonstigeto give a suspension
5. 5
   FiltrationThe solid was then filtered off
6. 6
   Waschenwashed with water
7. 7
   Trocknen1:3, Ethyl Acetate:Petroleum ether, dried
8. 8
   Filtrationover filter funnel in vacuo
9. 9
   Sonstigeto yield a gray solid
10. 10
    SonstigeA synthetic reaction scheme

Vorschrift

A mixture of 3-chloro-6-phenyl-4-(pyridin-4-yl)pyridazine (MW01-7-076WH) (0.5 mmol), 2-Morpholin-4-yl-ethylamine (2.0 mmol) in 3 ml of 1-BuOH was heated with stirring at 130° C. for about 7 days. The solvent was removed by evaporation in vacuo, the residue was treated with water to give a suspension. The solid was then filtered off, washed with water, then 1:3, Ethyl Acetate:Petroleum ether, dried over filter funnel in vacuo to yield a gray solid. ESI-MS: m/z 362.2 (M+H+). A synthetic reaction scheme for the preparation of 3-(4-methylpiperazin-1-yl)-N-(2-morpholinoethyl)-6-phenyl-4-(pyridin-4-yl)pyridazin-3-amine (MW01-7-091WH) is depicted in FIG. 10.

Quelle