Reaktion #470392

Reaktionsgleichung

2,6-diisopropylaniline

2-fluoronitrobenzene

potassium fluoride

→

desired product

Ausbeute 47.9%

2,6-diisopropyl-N-(2-nitrophenyl)aniline

Ausbeute 47.9%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooled to room temperature
2. 2
   ExtraktionThe mixture was then extracted with dichloromethane (200 mL) for three times
3. 3
   SonstigeThe solvent was evaporated
4. 4
   Sonstigethe residue was purified by column chromatography

Vorschrift

2,6-diisopropylaniline (25 g, 141 mmol), 2-fluoronitrobenzene (10 g, 70 mmol), and potassium fluoride (6.2 g, 106 mmol) were mixed in a one-neck flask. The mixture was heated up to 180° C. under nitrogen for 48 hours. After cooled to room temperature, water (200 mL) was added. The mixture was then extracted with dichloromethane (200 mL) for three times. The solvent was evaporated and the residue was purified by column chromatography using 20% of dichloromethane in hexanes. 10 g of desired product was obtained.

Quelle