Reaktion #470391

Reaktionsgleichung

2-phenyl-1H-benzo[d]imidazole

ethanol

→

desired product

1-(2-isopropylphenyl)-2-phenyl-1H-benzo[d]imidazole

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was heated up
2. 2
   Temperaturto reflux for 24 hours
3. 3
   Filtrationthe precipitate was collected by filtration
4. 4
   SonstigeThe product was purified by column chromatography

Vorschrift

Intermediate 1 (1.5 g, 2.1 mmol) and 142-isopropylphenyl)-2-phenyl-1H-benzo[d]imidazole (2 g, 6.4 mmol) were mixed with 30 ml of ethanol in a three-neck flask under nitrogen. The mixture was heated up to reflux for 24 hours. After cooled to room temperature, the precipitate was collected by filtration. The product was purified by column chromatography using 1:2 dichloromethane and hexanes as eluent. 0.7 g of desired product was obtained after purification.

Quelle