Reaktion #470377

Reaktionsgleichung

cyclen

2-bromo-5-(1,3-dioxo-1,3-dihydroisoindol-2-yl)pentanoic acid benzyl ester

→

product

Ausbeute 81.3%

5-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-2-(1,4,7,10-tetraazacyclododec-1-yl)pentanoic acid benzyl ester

Ausbeute 81.3%

Lösungsmittel

CH3CN

CH3CN

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONare added dropwise
2. 2
   FiltrationThe precipitate is filtered off
3. 3
   Waschenwashed thoroughly with acetonitrile

Vorschrift

55 g of cyclen base (320 mmol) are dissolved in 550 ml of CH3CN, to which 119.8 g of brominated derivative (2-bromo-5-(1,3-dioxo-1,3-dihydroisoindol-2-yl)pentanoic acid benzyl ester, 288 mmol) dissolved in 550 ml of CH3CN are added dropwise. The medium is stirred at ambient temperature overnight. The precipitate is filtered off and washed thoroughly with acetonitrile. 138 g of product are obtained in the form of a white powder (corrected yield 81.3%).

Quelle