Reaktion #470375

Reaktionsgleichung

N-isopropylpyrrolidine

chloromethyl methyl ether

→

desired product

N-Methoxymethyl-N-Isopropylpyrrolidinium Chloride

Lösungsmittel

2-butanone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was thereafter heated to a gradually elevated temperature
2. 2
   Sonstigewhereby the reaction was terminated
3. 3
   TemperaturThe reaction mixture was cooled to 5° C.
4. 4
   Filtrationthe resulting solids were filtered off in nitrogen
5. 5
   WaschenThe filter cake was washed with 200 ml of 2-butanone
6. 6
   Sonstigedried in a vacuum

Vorschrift

A 40.00 g quantity of N-isopropylpyrrolidine was dissolved in 361 g of dehydrated 2-butanone (reagent, product of Wako Pure Chemical Ind. Ltd.), followed by replacement with nitrogen. To the solution was added dropwise 28.76 g of chloromethyl methyl ether (reagent, product of Tokyo Kasei Co., Ltd. as purified by distillation) at 5° C. over a period of 0.5 hour. The mixture was thereafter heated to a gradually elevated temperature and stirred at room temperature for 10 hours, whereby the reaction was terminated. The reaction mixture was cooled to 5° C., and the resulting solids were filtered off in nitrogen. The filter cake was washed with 200 ml of 2-butanone and thereafter dried in a vacuum, giving 66.40 g of the desired product.

Quelle