Reaktion #470373

Reaktionsgleichung

N-propylpyrrolidine

chloromethyl ethyl ether

→

white solid

N-Methoxymethyl-N-Propylpyrrolidinium Chloride

Lösungsmittel

acetone

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewhereby the reaction was terminated
2. 2
   FiltrationThe reaction mixture was filtered
3. 3
   Waschenwashed with 100 g of acetone
4. 4
   Sonstigedried in a vacuum

Vorschrift

A 36.33 g quantity of N-propylpyrrolidine was dissolved in 186 g of dehydrated acetone (up to 0.1% in water content), followed by replacement with nitrogen. To the solution was added dropwise 25.76 g of chloromethyl ethyl ether (reagent, product of Tokyo Kasei Co., Ltd. as purified by distillation) at 5° C. over a period of 1 hour. The mixture was stirred at 5° C. for 5 hours, whereby the reaction was terminated. The reaction mixture was filtered, washed with 100 g of acetone and dried in a vacuum, giving 58.10 g of a white solid product.

Quelle