Reaktion #470362

Reaktionsgleichung

ethyldimethylamine

chloromethyl methyl ether

→

N-ethyl-N-methoxymethyl-N,N-dimethylammonium chloride

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto terminate
2. 2
   Sonstigethe reaction
3. 3
   TemperaturThe reaction mixture was cooled to 5° C.
4. 4
   Filtrationthe resulting solids were filtered off in nitrogen
5. 5
   WaschenThe filter cake was washed with 150 g of acetone
6. 6
   Sonstigedried in a vacuum

Vorschrift

A 47.50 g quantity of ethyldimethylamine (reagent, product of Tokyo Kasei Co., Ltd.) was dissolved in 300 g of dehydrated acetone (reagent, Wako Pure Chemical Ind. Ltd.), followed by replacement with nitrogen. To the solution was added dropwise 52.30 g of chloromethyl methyl ether (reagent, product of Tokyo Kasei Co., Ltd. as purified by distillation) at 5° C. over a period of 1 hour. The mixture was thereafter stirred at a temperature of not higher than 15° C. for 5 hours to terminate the reaction. The reaction mixture was cooled to 5° C., and the resulting solids were filtered off in nitrogen. The filter cake was washed with 150 g of acetone, and thereafter dried in a vacuum, giving 85.90 g of N-ethyl-N-methoxymethyl-N,N-dimethylammonium chloride (white solid).

Quelle