Reaktion #47035

Reaktionsgleichung

intermediate 25

cis-4,5-Diphenylimidazolidine-2-thione

4-chloromethylbenzoic acid ethyl ester

→

product 205

Ausbeute 78.1%

4-[(cis-4,5-Diphenyl-4,5-dihydro-1H-imidazol-2-yl)thiomethyl]benzoic acid ethyl ester hydrochloride

Ausbeute 78.1%

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated to dryness
2. 2
   FiltrationThe insoluble material is filtered

Vorschrift

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 4-chloromethylbenzoic acid ethyl ester (0.268 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 278 mg of the product 205. 1H NMR (DMSO-d6) δ 11.20 (s, 2 H), 8.00 (d, 2 H), 7.75 (d, 2 H), 7.15-6.90 (m, 6 H), 6.90-6.65 (m, 4 H), 5.78 (s, 2 H), 4.90 (s, 2 H), 4.35 (q, 2 H), 1.32 (t, 3 H); MS: m/z 417 (M++1).

Quelle