Reaktion #470349

ord-ea21751830674f9bb21e0d3802af75e1

Reaktionsgleichung

COC(=O)[C@H](CCSC)NC(=O)c1ccc(C=O)cc1-c1ccccc1C
N-[4-formyl-2-(2-methylphenyl)benzoyl]methionine methyl ester
Cl.NC1c2ccccc2-c2ccccc21
9-aminofluorene hydrochloride salt
→
COC(=O)[C@H](CCSC)NC(=O)c1ccc(CNC2c3ccccc3-c3ccccc32)cc1-c1ccccc1C
desired compound
COC(=O)[C@H](CCSC)NC(=O)c1ccc(CNC2c3ccccc3-c3ccccc32)cc1-c1ccccc1C
N-[4-(N-(Fluoren-9-yl)aminomethyl)-2-(2-methylphenyl)benzoyl]methionine methyl ester

Edukte

COC(=O)[C@H](CCSC)NC(=O)c1ccc(C=O)cc1-c1ccccc1C
N-[4-formyl-2-(2-methylphenyl)benzoyl]methionine methyl ester
Cl.NC1c2ccccc2-c2ccccc21
9-aminofluorene hydrochloride salt

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The desired compound was prepared using the method described in Example 403H starting with N-[4-formyl-2-(2-methylphenyl)benzoyl]methionine methyl ester, prepared as in Example 403G, and 9-aminofluorene hydrochloride salt m/e (ESI) 551 (MH+)

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06310095B1uspto-grants-2001_10