Reaktion #47031

Reaktionsgleichung

intermediate 25

cis-4,5-Diphenylimidazolidine-2-thione

benzyl chloride

→

product 201

Ausbeute 42.8%

2-(Benzylthio)-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride

Ausbeute 42.8%

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated to dryness
2. 2
   FiltrationThe insoluble material is filtered

Vorschrift

A mixture of intermediate 25 (200 mg, 0.786 mmol) and benzyl chloride (0.184 mL, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 128 mg of the product 201. 1H NMR (DMSO-d6) δ 11.30 (s, 2H), 7.70-7.50 (m, 2 H), 7.50-7.35 (m, 3 H), 7.20-6.95 (m, 6 H), 6.90-6.70 (m, 4 H), 5.78 (s, 2H), 4.90 (s, 2 H); MS: m/z 345 (M++1).

Quelle