Reaktion #470246

ord-c9efbc9b39db4d63a3aea5f0da4e858a

Reaktionsgleichung

Cc1cc(C(=O)O)ccc1N
4-Amino-3-methylbenzoic acid
CC(C)(C)OC(=O)Nc1ccc(C(=O)O)cc1
N-BOC-4-aminobenzoic acid
Cc1cc(C(=O)O)ccc1NC(=O)OC(C)(C)C
desired product
Cc1cc(C(=O)O)ccc1NC(=O)OC(C)(C)C
N-BOC-4-Amino-3-methylbenzoic acid

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe resulting orange-brown solid was recrystallized from ethyl acetate and hexanes

Vorschrift

4-Amino-3-methylbenzoic acid (5 g, 33.1 mmol) was reacted according to the same procedure as that used in the process for preparing N-BOC-4-aminobenzoic acid. The resulting orange-brown solid was recrystallized from ethyl acetate and hexanes to provide the desired product (4.99 g) as tan prismatic crystals: m.p. 180-182° C.;

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06310095B1uspto-grants-2001_10