Reaktion #47001

Reaktionsgleichung

Hydrogen chloride

3-phenypropionitrile

methanol

→

product 242

3-Phenylpropionimidic acid methyl ester hydrochloride

Lösungsmittel

Et2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solid that formed
2. 2
   Filtrationfiltered

Vorschrift

Hydrogen chloride is bubbled into a cold (0° C.) solution of 3-phenypropionitrile (5.43 g, 41.4 mmol) in methanol (2.5 mL, 62.1 mmol) for 5 min, and the mixture stirred at rt for 3 h. The solid that formed is suspended in Et2O and filtered to give 7.8 g of the product 242. 1H NMR (CDCl3) δ 12.65 (s, 1 H), 11.65 (s, 1 H), 7.40-7.15 (m, 5 H), 4.24 (s, 3 H), 3.08 (s, 4 H)

Quelle