Reaktion #46994

Reaktionsgleichung

cis-4,5-bis-(2-methylphenyl)imidazolidine-2-thione

cis-4,5-bis-(2-Methylphenyl)imidazolidine-2-thione

methyl iodide

→

product 46

Ausbeute 96.3%

cis-4,5-bis-(2-Methylphenyl)-2-methylthio-4,5-dihydro-1H-imidazole hydroiodide

Ausbeute 96.3%

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated in vacuo
2. 2
   FiltrationThe insoluble material is filtered

Vorschrift

A mixture of cis-4,5-bis-(2-methylphenyl)imidazolidine-2-thione (29) (6.08 g, 0.0215 mol) and methyl iodide (2.01 mL, 0.0323 mol) in abs. EtOH (50 mL) is heated at 85° C. overnight. The reaction mixture is cooled to rt, concentrated in vacuo, and the residue suspended in Et2O. The insoluble material is filtered to give 8.79 g of the product 46. 1H NMR (DMSO-d6) δ 10.67 (s, 2 H), 7.10-6.90 (m, 8 H), 6.02 (s, 2 H), 2.79 (s, 3 H), 2.16 (s, 6 H); MS: m/z 297 (M++1).

Quelle