Reaktion #46975

Reaktionsgleichung

18

5-Bromo-1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-yl amine

AIBN

Bu3SnH

→

compound 19

Ausbeute 90.0%

1-(4-Methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-ylamine

Ausbeute 90.0%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto reflux for 15 h
2. 2
   TemperaturAfter cooling
3. 3
   Sonstigethe reaction mixture was evaporated
4. 4
   Extraktionextracted by CH2Cl2
5. 5
   TrocknenThe combined organic layer was dried by MgSO4
6. 6
   Einengenconcentrated
7. 7
   Sonstigeto give a residue that
8. 8
   Sonstigewas purified by silica gel flash column chromatography (EtOAc:n-hexane=1:2)

Vorschrift

To a stirred solution of 18 (2 g, 4.84 mmol), AIBN (0.08 g, 0.48 mmol), Bu3SnH (3.91 ml, 14.50 mmol) in toluene (49 ml) was heated to reflux for 15 h. After cooling, the reaction mixture was evaporated and then extracted by CH2Cl2. The combined organic layer was dried by MgSO4 and concentrated to give a residue that was purified by silica gel flash column chromatography (EtOAc:n-hexane=1:2) to give compound 19, yield 90%.

Quelle