Reaktion #46964

ord-284a7f1bb14041a2acb5c560ed9b9880

Reaktionsgleichung

COc1ccccc1CCC(=O)Nc1sc2c(c1C#N)CCN(C(=O)OCCOC(C)=O)C2
3-Cyano-2-[3-(2-methoxy-phenyl)-propionylamino]-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid 2-acetoxy-ethyl ester
→
COc1ccccc1CCC(=O)Nc1sc2c(c1C#N)CCN(C(=O)OCCO)C2
3-Cyano-2-[3-(2-methoxy-phenyl)-propanoylamino]-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid 2-hydroxy-ethyl ester

Edukte

COc1ccccc1CCC(=O)Nc1sc2c(c1C#N)CCN(C(=O)OCCOC(C)=O)C2
3-Cyano-2-[3-(2-methoxy-phenyl)-propionylamino]-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid 2-acetoxy-ethyl ester

Reagenzien

Keine

Lösungsmittel

[Na+].[OH-]
NaOH

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    FiltrationAfter acidification with aqueous HCl the precipitated product is filtered off

Vorschrift

3-Cyano-2-[3-(2-methoxy-phenyl)-propionylamino]-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid 2-acetoxy-ethyl ester (Example 31) is stirred in 1N NaOH over night at room temperature. After acidification with aqueous HCl the precipitated product is filtered off and recristalized from ethanol.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07741488B2uspto-grants-2010_06