Reaktion #46959

Reaktionsgleichung

acetonitrile

2-amino-4,5,6,7-tetrahydro-benzothiazole-6-carboxylic acid ethyl ester

2-amino-4,5,6,7-tetrahydro-benzothiazole-6-carboxylic acid ethyl ester hydrobromide

acetic anhydride

→

2-acetylamino-4,5,6,7-tetrahydro-benzothiazole-6-carboxylic acid ethyl ester

Ausbeute 120.1%

Lösungsmittel

triethylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA 500 ml reactor equipped with mechanical stirrer
2. 2
   TemperaturThe suspension was refluxed
3. 3
   Sonstigeobtaining complete
4. 4
   workup.DISSOLUTIONdissolution at a temperature
5. 5
   Sonstigeranging from 70 to 75° C
6. 6
   EinengenAfter approx. 2 hours 30 minutes the solution was concentrated to dryness
7. 7
   Sonstigethe residue was crystallized from 450 ml of isopropanol

Vorschrift

A 500 ml reactor equipped with mechanical stirrer, thermometer and condenser was loaded with 280 ml of acetonitrile, 71 g of 2-amino-4,5,6,7-tetrahydro-benzothiazole-6-carboxylic acid ethyl ester [(III), R1=ethyl] and 38.75 g of acetic anhydride. 38.03 g of triethylamine were dropwise added to the resulting suspension in about 10 minutes. The suspension was refluxed, obtaining complete dissolution at a temperature ranging from 70 to 75° C. After approx. 2 hours 30 minutes the solution was concentrated to dryness, and the residue was crystallized from 450 ml of isopropanol to obtain 74.5 g of 2-acetylamino-4,5,6,7-tetrahydro-benzothiazole-6-carboxylic acid ethyl ester.

Quelle