Reaktion #469445

Reaktionsgleichung

1-(4-fluorophenoxy)-2,3-epoxypropane

1-(indol-4yl)-piperazine

→

solid

Ausbeute 99.3%

1-(4-Fluoro-phenoxy)-3-[4-(1H-indol-4-yl)piperazin-1-yl]-propan-2-ol

Ausbeute 99.3%

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture was concentrated in vacuo
2. 2
   Sonstigethe product purified by silica gel chromatography (EtOAc)

Vorschrift

A methanolic solution (50 ml) of 1-(4-fluorophenoxy)-2,3-epoxypropane (0.50 g, 3.0 mmole) and 1-(indol-4yl)-piperazine (0.6 g, 3.0 mmole) was refluxed for 1 hr under an atmosphere of nitrogen. The mixture was concentrated in vacuo, and the product purified by silica gel chromatography (EtOAc) to afford a white solid (1.1 g, 99%). Treatment with a 0.25M ethanolic fumaric acid solution gave the required salt, which was recrystallized from ethanol to afford the title compound as a white solid. m.p. 234-235° C.

Quelle