Reaktion #469180

Reaktionsgleichung

2-(3,4-difluorophenyl)-4-(2-hydroxy-2-methyl-1-propoxy)-5-[4-(aminosulfonyl)phenyl]-3(2H)-pyridazinone

acetic anhydride

triethylamine

→

title compound

N-[[4-[2-(3,4-Difluorophenyl)-4-(2-hydroxy-2-methyl-1-propoxy)-2H-pyridazin-3-on-5-yl]phenyl]sulfonyl]acetamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture is partitioned between ethyl acetate and water
2. 2
   WaschenThe organic layer is washed with brine
3. 3
   Trocknenthen dried over MgSO4
4. 4
   Filtrationfiltered
5. 5
   EinengenThe filtrate is concentrated in vacuo

Vorschrift

A mixture of 2-(3,4-difluorophenyl)-4-(2-hydroxy-2-methyl-1-propoxy)-5-[4-(aminosulfonyl)phenyl]-3(2H)-pyridazinone (Example 459, 1 equivalent), acetic anhydride (3 equivalents), 4-(dimethylamino)pyridine (0.3 equivalents), and triethylamine (1.2 equivalents) is stirred at room temperature for 16 hours. The reaction mixture is partitioned between ethyl acetate and water. The organic layer is washed with brine then dried over MgSO4 and filtered. The filtrate is concentrated in vacuo to give the title compound.

Quelle