Reaktion #46917

Reaktionsgleichung

2,4′-dibromoacetophenone

ethyl acetoacetate

potassium carbonate

→

title compound

ethyl 2-acetyl-4-(4-bromophenyl)-4-oxobutanoate

Lösungsmittel

2-butanone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 24 hours
2. 2
   TemperaturUpon cooling
3. 3
   Filtrationthe mixture was filtered over diatomaceous earth
4. 4
   Einengenconcentrated
5. 5
   SonstigeThe residue was purified by chromatography with DCM

Vorschrift

A mixture of 2,4′-dibromoacetophenone (3.0 g, 10.8 mmol), ethyl acetoacetate (1.48 mL, 10.8 mmol) and potassium carbonate (4.5 g, 32.4 mmol) were heated in 2-butanone (50 mL) at reflux for 24 hours. Upon cooling, the mixture was filtered over diatomaceous earth and concentrated. The residue was purified by chromatography with DCM to provide the title compound as an oil. 1H NMR (CDCl3) δ ppm 1.30 (3H), 2.10 (3H), 3.19 (2H), 3.75 (1H), 4.15 (2H), 7.50 (2H), 7.81 (2H); MS (ESI) m/z 326/328.

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