Reaktion #468782

Reaktionsgleichung

3,9-dimethylbenzo[f]quinazolin-1(2H)-one

NaH

Bromomethyl methyl ether

→

3,9-dimethyl-2-methoxymethylbenzo[f]quinazolin-1(2H)-one

Lösungsmittel

DMF

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe solution was stirred at room temperature overnight
2. 2
   Extraktionextracted twice with methylene chloride (100, 40 ml)
3. 3
   WaschenThe combined methylene chloride extracts were washed with a small volume of water
4. 4
   Trocknendried (K2CO3)
5. 5
   Einengenconcentrated in vacuo
6. 6
   SonstigeThe residue was purified by silica gel (4 0 g) chromatography
7. 7
   Wascheneluting with ethyl acetate

Vorschrift

To a suspension of 3,9-dimethylbenzo[f]quinazolin-1(2H)-one (1.0 g, 4.5 mmol) in DMF (25 ml) was added 80% NaH (0.15 g, 5.0 mmol) (Aldrich) portion wise and the mixture was stirred 35 minutes. Bromomethyl methyl ether (0.39 ml, 4.8 mmol) (Aldrich) was added in one portion and the solution was stirred at room temperature overnight. The solution was then diluted with water (100 ml) and extracted twice with methylene chloride (100, 40 ml). The combined methylene chloride extracts were washed with a small volume of water, dried (K2CO3), and concentrated in vacuo. The residue was purified by silica gel (4 0 g) chromatography eluting with ethyl acetate:methylene chloride (0 to 1:19) to give 3,9-dimethyl-2-methoxymethylbenzo[f]quinazolin-1(2H)-one and the corresponding O-alkylated material in a 4:1 ratio as determined by NMR (0.79 g). 1H NMR (DMSO-d6, 300 MHz) for major isomer δ: 2.57 (s, 3H, C9—CH3), 2.68 (s, 3H, C3—CH3), 3.38 (s, 3H, OCH3), 5.62 (s, 2H, NCH2O), 7.51 (dd, J=8,2 Hz, 1H, Ar), 7.56 (d, J=9 Hz, 1H, Ar), 7.96 (d, J=8 Hz, 1H, Ar), 8.24 (d, J=9 Hz, 1H, Ar), 9.63 (s, 1H, Ar). Anal. Calculated for C16H6N2O2: C, 71.62; H, 6.01; H, 10.44. Found: C, 71.55; H, 6.03; H, 10.43.

Quelle